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KMID : 0360319950270061017
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Journal of Korean Cancer Research Association
1995 Volume.27 No. 6 p.1017 ~ p.1029
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Multidrug Reslstance(MDR 1) Gene Expression in Adult Acute Leukemia: Expression of P-glycoprotein and MDR 1 mRNA and its implication on clinical outcome in adult
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김형준
정익주/서재성/최경상/박무림/백광우/배열
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Abstract
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Resistance to multiple chemotherapeutic agents is mainly related to the production of P-glycoproteins, a transmembrane drug efflux pump that is encoded by the multidrug resistance(MDR) gene. MDR I. To investigate whether MDR 1 could be involved
in
clinical resistance to chemotherapy in adult acute leukemias. We have analyzed prospectively 39 samples from 32 patients(27 at presentation, 5 after relapse) with acute leukemia for the evaluation of overexpression of MDR 1 mRNA and
P-glycoprotein
by
using polymerase chain reactions(PCR) and flow cytometric assay, respectively. The induction rate of first complete remission differed between MDR 1 mRNA-positive and negative proups(37% v 84%, respectively; p=0.02).
The survival rate(Kaplan-meier method) in MDR 1 mRNA negative group was significantly higher than that in MDR 1 mRNA positive group(p=0.02). These results suggest that PCR assay of MDR 1 mRNA is a convenient method to detect expression of MDR 1
gene,
and it may be a prognostic factor in the treatment of acute leukemia.
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